I wonder why don’t the embryo / blastocyst attach to the uterus?

There can be several reasons for implantation failure. Firstly, the embryo may have a wrong chromosome set, which makes the embryo’s development stop (for example right after getting into the uterus). Secondly, in the uterine cavity, there is often a specific issue that reduces endometrial receptivity (such as adenomyosis, inflammation, etc.). Often, these causes are not visible with just ultrasound. Thirdly, the dialogue between the embryo and the endometrium may be impaired. The embryo might be wonderful and the endometrium might be overall ready, but not at the specific time when the embryo transfer took place. Instead, it might be a little earlier or a little later. In each individual case, these causes may occur as just one, or as a combination of them. Studying the patient’s history of previous conception attempts, we can suspect one or another.

Dr. Elena Lapina

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BØRSEN Weekend, Denmark | 11 April 2025 | By Rikke Agnete Dam | Photo: Sigrid Ellesøe | Translation: Anna Svarinskaya

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