Marie and Erik came to us after 4 IVFs and 10 ETs in Sweden with only two biochemical pregnancies as a result and got their child after the first ET in OLGA Clinic, using individualized IVF with their own eggs and sperm

Marie and Erik, July 2023:

"We heard about the OLGA Clinic through a friend that had heard about the clinic from another patient that now has twins with the help from OLGA. We were a bit skeptical in the begging to go to Russia but after 4 IVF treatments with 10 embryo transfers in Sweden without success we felt this was our last chance.

We were offered the Money back guarantee program, with our own eggs, which we felt was reassuring as the clinic was also invested in our success.

When we got the treatment plan and later was on site in St Petersburg we felt very much taken care of and that the program was a lot more individualized than in Sweden where we felt everything was more or less being done the same way treatment after treatment.

Long story short, it took us only one attempt to get pregnant and now we are sitting with our 1 week old son in our arms. We are very grateful to all of the staff that have had our best in mind and been very supportive. We also felt it was a huge difference in the contact with the doctors and we always had a way to get a response to our questions even during the weekend when something alarming occurred.

Thank you OLGA Clinic from the bottom of our heart for your help.

Marie & EriK, July 2023"

What has helped?

Medical history

Marie, 35, healthy. AMH in December 2021 4.5 mcg/L.

Erik, 31, healthy. Sperm test in November 2020, concentration 22 million/ml, motility 45%.

1 natural biochemical pregnancy and then 4 egg retrievals, 10 embryo transfers of 12 blastocysts altogether and 2 biochemical pregnancies after IVF in current

Hysteroscopy in Sweden 2021 between ET 5 and 6. No abnormalities found.

A bit of maths

In average 4 blastocysts were available for transfer per one IVF attempt.

At the age of 36 one out of two blastocysts is expected to carry a normal set of chromosomes.

Hence, we might expect 2 chromosomally normal blastocysts per one IVF attempt.

Couples with RIF and RPL usually need more than one embryo transfer of a chromosomally normal blastocyst to achieve birth due to a huge influence of maternal factors.

So, we offered a shared risk package "3 x own egg IVF package" with a guarantee of a live birth or money back.

Stimulation

IVF №1, Aug 2019, Sweden
Gonal-F 112,5 IU for 7 days and 100 IU for 3 days. Orgalutran from day 5. Ovitrelle on day 12

IVF №2, Aug 2020, Sweden
Gonal-F 112,5 IU 8 days. Fyremadel from day 5.  Suprefact on day 9

IVF №3, Nov 2020, Sweden
Menopur 112,5 IU 10 days. Antagonist from day 5. Suprefact on day 11

IVF №4, Mar 2021 Sweden
Gonal-F 75 IU + Menopur 75 IU 10 days. Fyremadel from day 5. Agonist on day 11

IVF №5 May 2022 OLGA Clinic St. Petersburg
Gonal 112,5 IU 13 days, Orgalutran from day 8, Decapeptyl 0,2 on day 13

At OLGA Clinic

Supplements to boost egg and sperm competence and vitality

Creating competent eggs and viable embryos

• US SD 1 to exclude leading follicle before stimulation begin
• Antagonist protocol Gonal F 112.5 IU
• US SD5, SD7 to choose the day of Orgalutran begin
• Orgalutran from SD8 (from 14mm follicle)
• US SD9 and SD12 to choose the day for the trigger
• Trigger Decapeptyl 0,2 on SD 13

Finding out reasons of repeated implantation failure and early  miscarriages

At hysteroscopy October 2021 in Sweden there are no anatomical problems, no adhesions, polyps or myomas were seen. Normal anatomy of the uterine cavity with the normal view of tubal ostia is described.

At hysteroscopy July 2022 at OLGA Fertility clinic:
Arcuate uterus, inflammatory process in the uterine cavity was suspected (uneven endometrium color, increased vascular pattern), visual features of viral endometritis and cervicitis (papilloma).

Histology: Endometrium of the early stage of the secretion phase with mild edema, focal hemorrhages, focal periglandular mononuclear infiltration in the stroma, small tangles of spiral arteries.

Immunohistochemical examination: CD 8: 15-20 cells (norm <10 cells in the field of view x400),
CD 20: 12-20 cells (<3 cells -//-), CD 138: 1-3 cells (0-1 cells -//-)

PCR from the uterus cavity: Gardnerella, candida.

Conclusion: arcuate uterus, chronic endometritis of moderate activity. Signs of a combined bacterial, fungal and viral inflammation.

ERA test — receptive endometrium 129 hours after progesterone beginning.

Preparing optimal environment in the uterus and in the body for the VIP Embryo

July 2022 two types of antibiotics ( doxycycline, ornidazole for two weeks), antifungal medication (fluconazole) and treatment to prevent adhesions formation ( hyaluronidase).

August-September 2022 complex antibacterial, antiviral and immune-modulating therapy ( Inosin pranobex for 1 month, interferon a-2b –two courses 10 days each, metronidazole 7 days, oral probiotic for one month)

October 2022 transfer of a single Euploid  blastocyst by ERA test

July 2023 a beautiful baby-boy Henri 3880 gr 52 cm!

What helped OLGA Team achieve a baby within just one embryo transfer after 4xIVF/10xETs

• 1. Focus on egg maturity and competence which helped achieve excellent fertilization

• 2. Excellent fertilization and cultivation techniques which brought 8 blastocysts

• 3. PGT-A helped to select a chromosomally normal blastocyst for ET
  5 chromosomally normal blastocysts are not a success of PGTA. It is a success of optimal ovarian simulation that help to get a competent cohort of mature eggs and of the excellent laboratory process that brought enough viable blastocysts to find so many with normal chromosome sets.
• 4. Optimization of uterus Thorough investigation of the uterus revealed several bacterial and viral reasons of inflammation and recurrent pregnancy loss (2 out of 10 embryo transfers done in Sweden resulted in early miscarriage, one naturally achieved pregnancy was lost earlier)
  — Combined antibacterial, antiviral and immunomodulating therapy prepared the environment in the uterus and the whole body for keeping the pregnancy
• 5. Continuous medical advice during the whole pregnancy up until live birth supported pregnancy and helped to achieve live birth

Acknowledgements

To Dr. Alena Egorova for analyzing all the data from Marie and Erik and believing in their success using own eggs and own sperm

Dr. Svetlana Murashko for creating exceptionally competent eggs which made it possible to achieve excellent fertilization by conventional IVF and grow viable blastocysts

Dr. Svetlana Shlykova and Dr. Maia Shestakova for excellent embryology

Dr. Elena Lapina for thorough hysteroscopy and individual consulting

Dr. Svetlana Murashko for diagnostics and treatment of maternal reasons of miscarriages and individualized preparation to embryo transfer, which made it possible for the body to keep the pregnancy

Ekaterina Tint and Dr. Olga Romanova for following through the whole pregnancy

Eugenia Lovyagina / Anastasia Potanina for communication, logistics, coordination and support on distance and in St. Petersburg