Olga and Lars came to us after 3 unsuccessful IVF cycles in Denmark and got their baby girl on the very first attempt by OLGA Fertility in collaboration with lovely colleagues in Cyprus, using individualized IVF with own eggs, PGT-A and live birth money back guarantee.
What has helped? — Keep reading and you will find out! With the kind permission of the couple we are sharing with you our medical presentation explaining the treatment which has helped them have their daughter.
Olga and Lars:
“Our IVF journey began in 2019. After three inseminations and three IVF treatments without success, the doctors in Denmark assured us nothing was wrong — just bad luck.
Following our third IVF attempt, we turned to the OLGA clinic. Based on our medical history, they recommended a three-cycle IVF package with a baby guarantee, which we pursued in Cyprus...
During our first visit in Cyprus in June 2023, the doctor discovered fluid in my right fallopian tube, potentially creating a toxic environment for implantation — something missed in over 40 ultrasounds in Denmark. Surgery in September confirmed a severe infection and scar tissue around both tubes and the uterus. The surgeon told us that it was lucky that the doctor detected this during the ultrasound in Cyprus.
In December 2023, we returned to Cyprus for the embryo transfer. On December 18th, I saw my first-ever positive pregnancy test. We never expected to get pregnant on the first attempt, so we were a bit shocked, yet incredibly happy.
It was a challenging pregnancy, but the clinic provided incredible support every step of the way.
Today, we have a healthy six-month-old daughter, all thanks to the OLGA clinic.
We are forever grateful for their support, expertise, and transparency throughout this journey. The whole team have been so informative, which has also given us a better understanding of our situation.”
To find out what has helped Olga and Lars achieve successful pregnancy and birth after 3 failed IVF cycles in Denmark, continue reading below.
Medical history by the first consultation in OLGA Clinic, March 2023
Olga:
- 34 years old, healthy.
- No pregnancies before,
- AMH 10/02/23 :13 pmol/l (1,86 mcg/L) AFC about 7+6
- In February 2020: hydrosonography (HSG), normal passage through both fallopian tubes.
- In July 2022: hysteroscopy, endometrial polyp removal
Lars:
- 34 years old, healthy
- Sperm test: 5.5 ml, concentration 45 mln/ml, 56% progressive motility, 72% total motility
- Trying for a baby since 2016
- 3 IUI in 2020, 3 egg retrievals and 3 fresh ETs in blastocyst stage in 2020-2022
- No pregnancy
Having all available details reviewed we accepted a challenge and approved 3xIVF package with own eggs and 100% money back guarantee of live birth
Stimulations
IVF №1, June 2020, Denmark
Gonal-F 225 IU for 8 days. Fyremadel from day 6. Double trigger: Ovitrelle + Suprefact 0,5 ml on day 9.
IVF №2, September 2020, Denmark
Fostimon 300 IU for 10 days, Luveris 75 IU from day 6. Fyremadel from day 6. Double trigger: Ovitrelle + Suprefact 0,5 ml on day 11.
IVF №3, March 2022, Denmark
Recovelle 12 mcg for 8 days, Luveris 75 IU from day 6. Fyremadel from day 6. Double trigger: Ovitrelle + Synarela 4 puffs on day 9.
IVF №4, June 2023, OLGA Fertility Cyprus
Gonal-F150+Menopur 150 IU for 11 days. Orgalutran from day 7. Double trigger Ovirelle+Decapeptyl 0,2 on day 12.
Supplements to boost egg and sperm competence and vitality 2,5 months before eggs and sperm collection
For Her:
- Coenzyme Q10 – 100 mg, 3 times daily
- Omega 3 – 1000-1600 mg daily
- Vitamin D 5000, than1000 IU daily
- Myoinositol – 2000 mg, 2 times daily
- Melatonin – 3 mg daily
- Folic Acid- 1000 mcg daily
- Iron supplement 100 mg daily
For Him:
- Coenzyme Q10 – 100 mg, 3 times daily
- Omega 3 – 2500-3500 mg daily
- Vitamin D 1000 IU daily
- Zinc – 15 mg daily
- Folic Acid- 2000 mcg daily
Creating competent eggs and viable embryos
- P-pills for 1 cycle to synchronize growth of the follicles.
- US 3 days before finishing P-pills to exclude presence of cysts or leading follicles.
- US SD 1`to exclude leading follicle before stimulation begin.
- Antagonist protocol Gonal F 150 IU+ Menopur 150 IU
- US SD5 to choose the day of Orgalutran begin
- Orgalutran from SD7
- US SD8 and SD11 to choose the day for the trigger
- Double trigger Ovitrelle + Decapeptyl 0,2 on SD 12
Finding out reasons of repeated implantation failure
A right-sided hydrosalpinx was suspected by our doctor Svetlana Murashko in Ultrasound examination performed in Cyprus during stimulation.
A presence of hydrosalpinx decreases implantation rates by 30%, compared to no hydrosalpinx.
12/09/2023 Laparoscopy and Hysteroscopy in Denmark. The hydrosalpinx confirmed, the right fallopian tube removed. Pelvic adhesions dissected.
No anatomical problems in uterus cavity found.
Histology: leucocytes infiltration — microscopic signs of inflammation in the endometrium.
The findings indicated a chronic inflammatory process in the uterus and right fallopian tube.
Therapy after the laparoscopy: antibacterial therapy (doxycycline 10 days), antifungal medication (fluconazole), Probiotics.
- November 2023: ERA+ ALICE+EMMA test.
- ERA test – endometrium receptive 129 h after the start of Progesterone
- EMMA+ALICE test: Escherichia coli (pathogen related to chronic endometritis) detected in endometrium sample.
- Therapy after EMMA test: antibacterial therapy (Amoksiklav for 10 days), antifungal medication (fluconazole), Probiotics.
- 07/12/2023 transfer of a single Euploid blastocyst by ERA test
16/07/24 a beautiful baby-girl Olivia came!
What helped OLGA team achieve a baby within just one embryo transfer after 3 failed IVF / 3ETs in Denmark?
- Focus on eggs energy and maturity which helped to get a competent cohort of eggs
- Excellent fertilization and cultivation techniques which brought 5 blastocysts
- PGT-A to exclude abnormal blastocysts and select the only one normal in the pool received. Only 1 out of 5 was chromosomally normal, which is lower than expected at the age of 34 (1 out of 2 is expected statistically).
- Thorough diagnostic process that allowed us to notice US symptoms of hydrosalpinx already during the first treatment cycle at our clinic.
- Excellently performed laparoscopy in Denmark with removal of hydrosalpinx.
- Thoughtful, complex anti-inflammatory therapy, based on all clinical findings.
- Strict timing of the embryo transfer based on ERA test.
- Continuous medical follow up to prevent a pregnancy loss and support during the whole pregnancy up until live birth.
Acknowledgements
Dr. Alena Egorova for analyzing all the data from Olga and Lars and believing in their success using own eggs and own sperm
Dr. Natalia Shpiller for creating exceptionally competent eggs which made it possible to achieve excellent fertilization by conventional IVF and grow viable blastocysts
Dr. Anna Gusareva for excellent embryology
Dr. Svetlana Murashko for diagnosing a hydrosalpinx
Colleagues in Denmark for excellent laparoscopy, removal of the pathological fallopian tube
Dr. Natalia Shpiller for diagnostics and treatment of maternal reasons of miscarriages and individualized preparation to embryo transfer, which made it possible for the body to keep the pregnancy
Dr. Andreas Bazeos for excellent Egg retrieval and Embryo transfer
Ekaterina Tint and Dr. Olga Romanova for following through the whole pregnancy
Diana Furshteyn and Natalya Glushkova for communication, logistics, coordination and support
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