Trine and Morten wrote to us shortly after birth:
"Theodor is here! He was born Saturday October 28th at 5:13 pm and he is just perfect :)
Weight: 2830 grams, height: 50 cm.
We are both doing well — recovering and relaxing at home.
We just wanted to send you and the team a BIG, BIG thank you for making our dream come true. Without the O.L.G.A clinic little Theodor would not have been here. We thank you from the bottom of our hearts
Thank you and the team for always being there for us. Even though you are based in Russia we've always felt that you have been closer than any other clinic here in Norway that we have visited. Thank you for believing in us when we had lost all hope We are so in love with our little bundle of joy.
Please send our regards to Darya, Dr Pavel, Dr Olga and all the other super helpers at the clinic
Best wishes from Theodor, Morten and Trine"
Why did all these beautiful blastocysts not stay? MRI revealed that Trine had a unicorn uterus...
What has helped Trine and Morten become parents using their own eggs, own
sperm and own uterus?
Medical history
Trine, 38
1 natural miscarriage and non-developing twin pregnancy after IVF
AMH in October 2021 = 32 pmol/L
Morten, 46
Healthy, normal sperm count
| IVF №1, December 2018, Norway | IVF №2, September 2019, Norway | IVF №3, August 2020, Norway | IVF №4, October 2020, Norway | IVF №5, January 2021, Norway | IVF №6, September 2021, Norway | IVF №7, February 2022, OLGA clinic St.Petersburg | IVF №8, December 2022, OLGA clinic St.Petersburg | |
|---|---|---|---|---|---|---|---|---|
| Eggs collected | 14 | 12 | 12 | 9 | 12 | 8 | 14 | 6 |
| Eggs fertilised | 6 | 8 | 6 | 6 | 8 | 4 | 11 | 3 |
| Blastocysts | 3 | 6 | 2 | 1 | 2 | No blastocysts | 6 | 2 |
| Chromosomally normal BL | Not tested | Not tested | Not tested | Not tested | Not tested | Not tested | 1 | 1 |
| Pregnancy | - | - | - | - | Non-developing twin pregnancy | - | Non-developing pregnancy | A baby |
Protocol
IVF №1, December 2018, Norway
Long protocol
IVF №2, September 2019, Norway
Long protocol
IVF №3, August 2020, Norway
Gonal-F 300 - 9 days. Antagonist from day 5. Ovitrelle day 10
IVF №4, October 2020, Norway
Gonal-F 300 -11 days. Antagonist from day 5. Ovitrelle day 12
IVF №5, January 2021, Norway
Gonal-F 350 - 10 days. Antagonist from day 6. Ovitrelle day 11
IVF №6, September 2021, Norway
Gonal-F 350 - 10 days. Antagonist from day 6. Ovitrelle day 11
IVF №7, February 2022, OLGA clinic St.Petersburg
Half-long protocol with Gonapeptyl 0.05 - 6 days before stimulation;
Gonal-F 187.5 + Menopur 112.5 11 days; Ovitelle day 12
IVF №8, December 2022, OLGA clinic St.Petersburg
Half-long protocol with Gonapeptyl 0.05 - 7 days before stimulation;
Gonal-F 187.5 + Menopur 112.5 10 days; Ovitelle day 11
IVF №7 at OLGA Clinic St. Petersburg, February 2022
Supplements to boost egg and sperm energy and vitality
For Her:
- Coenzyme Q10 – 100 mg
- Omega 3 – 1000-1600 mg daily
- Vitamin D 1000 IU daily
- Folic acid 1000 mcg daily
- Myoinositol – 2000 mg, 2 times daily
For Him:
- Omega 3 – 1000-1600 mg daily
- Folic acid 1000 mcg daily
- Vitamin D 1000 IU daily
- Myoinositol – 2000 mg, 2 times daily
Creating competent eggs and viable embryos
Ovarian stimulation
- P-pills for 1 cycle to synchronize growth of the follicles. US 3 days before finishing P-pills to exclude presence of cysts or leading follicles.
- US SD 1`to exclude leading follicle before stimulation begin
- Long protocol with Gonapeptyl 0.05 mg for 6-7 days before staring stimulation and during the whole stimulation Gonal F 187.5 IU + Menopur 112.5 IU
- US SD5-6, SD7-8 to monitor the process of follicles development
- US SD9-10 to choose the day for the trigger
- Trigger Ovitrelle 250mcg on SD 11-12
Optimizing embryonic reasons of repeated implantation failure
- 1st attempt:
14 eggs – 11 fertilized normally via IVF – 6 blastocysts – only 1 chromosomally normal → a missed abortion - 2nd attempt:
6 eggs – 3 fertilized normally via IVF – 2 blastocysts – 1 chromosomally normal → a baby
Only 2 out of 8 blastocysts were chromosomally normal – 25% (for the age of 38 usually 33%)
By using only chromosomally normal embryos for transfer we are increasing pregnancy rates, reducing miscarriage rates, increasing live birth rates and shortening time to successful pregnancy and live birth.
PGT-A increases chance of live birth per embryo transferred and shortens time to pregnancy and live birth
Diagnostics and treatment of maternal reasons of repeated implantation failure
At hysteroscopy + Ls in 2018 in Norway there were superficial endometrioid foci (electrocoagulation); bicorporeal uterus with a rudimentary right horn (without endometrium). The left horn is normal.
The MRI in 2018 confirmed that the right horn is rudimentary.
At hysteroscopy in OLGA Clinic April 2022 Unicornuate uterus. No endometriosis.
Histological exam showed polypoid type of the endometrium of the early stage of the secretory phase, fibrosis. Polyp of the endometrium.
ERA test 128h
Blood tests for thrombophilia, viruses and autoimmune diseases were normal.
Preparing optimal environment in the uterus and in the body for the VIP embryos
April 2022 – two types of antibiotics, normalization of microbiome, treatment against adhesions
June 2022 – transfer of a single Euploid blastocyst by ERA test (normal by 128h)
July 2022 – non-developing pregnancy
One more IVF round and transfer of the 2nd single Euploid blastocyst by ERA test in February 2023
October 2023 – Theodor was born
What helped OLGA Team to achieve a baby within 2 embryo transfers after multiple attempts in other clinics?
- Individualized stimulation to receive maximal number of viable blastocysts
- PGT-A to exclude abnormal blastocysts from usage
- Thorough investigation of the uterus to better understand its special unicorn anatomy and situation in endometrium
- Treatment of inflammation and adhesions
- Paying special attention to a unique uterus anatomy while embryo transfer procedure which helped to achieve pregnancies;
- Continuous medical follow up during the whole pregnancy up until live birth supported pregnancy and helped to achieve live birth
Acknowledgements
To Dr. Alenka Sirovec for analyzing all the data from Trine and Morten and believing in their success using own eggs and own sperm
Dr. Pavel Semenov for creating exceptionally competent eggs which made it possible to achieve excellent fertilization by conventional IVF and grow viable blastocysts
Dr. Svetlana Shlykova and Dr. Maia Shestakova for excellent embryology
Dr. Nina Bogdanova for thorough hysteroscopy
Dr. Pavel Semenov for diagnostics and treatment of maternal reasons of miscarriage and non-developing pregnancies and individualized preparation to embryo transfer, which made it possible for the body to keep the pregnancy
Olga Malysheva and Dr. Olga Romanova for following through the whole pregnancy
Anna Savelyeva/Darya Ivanova for communication, logistics, coordination and support on distance and in St. Petersburg
Lots of love and gratitude to Trine and Morten from the whole OLGA Team for being such lovelypatients and such a wonderful couple! It was a true pleasure to have you as patients in our clinic!
Without your mutual love and support this baby would not have become a reality!
To learn more about individualized IVF with money back guarantee of live birth, register to our seminars and webinars
To create your individual IVF process and achieve successful pregnancy and live birth book your free personal consultation with our doctors
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