{"id":11620,"date":"2022-09-14T08:07:28","date_gmt":"2022-09-14T08:07:28","guid":{"rendered":"https:\/\/olgafertilityclinic.com\/?page_id=11620"},"modified":"2025-03-13T06:27:12","modified_gmt":"2025-03-13T06:27:12","slug":"ivf-maths","status":"publish","type":"page","link":"https:\/\/olgafertilityclinic.com\/en\/ivf-maths\/","title":{"rendered":"IVF Math"},"content":{"rendered":"<p>Dr. Olga Zaytseff, an obstetrician-gynecologist and&nbsp;fertility specialist, the founder of O.L.G.A. Fertility:<\/p>\n<div class=\"inset w50p\"><a class=\"popup-youtube\" href=\"https:\/\/www.youtube.com\/watch?v=FVn57cJENdE\"> <img decoding=\"async\" class=\"w100p\" src=\"https:\/\/olgafertilityclinic.com\/wp-content\/uploads\/2023\/02\/video-ivf-maths-play.jpg\" \/> <\/a><\/p>\n<p class=\"caption\" style=\"margin-top: .2rem;\">Dr.\u00a0Olga Zaytseff<br \/>\nAn obstetrician-gynecologist and&nbsp;fertility specialist, the founder of O.L.G.A. Fertility<\/p>\n<\/div>\n<p><em>Let\u2019s start by defining what exactly we mean by the IVF success in&nbsp;O.L.G.A. Fertility. By the IVF success we mean not a completed IVF cycle, not a positive pregnancy test, and&nbsp;not even&nbsp;a clinical pregnancy. <b>By the IVF success we mean the achievement of a live birth.<\/b> <b>O.L.G.A.<\/b> Fertility <b>O<\/b>ffers<b> L<\/b>ivebirth<b> G<\/b>uarantee<b> A<\/b>ssurance, it works on&nbsp;a baby or&nbsp;money back principle.<\/em><\/p>\n<p><em>Here I will share with you how our knowledge and\u00a0skills <b>in\u00a0fertility, biology and\u00a0genetics\u00a0help us define prognosis, share risk, and\u00a0achieve successful birth in\u00a0many patients<\/b>, even\u00a0if\u00a0they could not have been helped anywhere else. I will also explain how we count the number of IVF attempts with own eggs sufficient for\u00a0achieving live birth. If\u00a0the number of expected IVF attempts till\u00a0live birth is realistic, a package with a fixed number of IVF attempts and\u00a0money back guarantee of live birth can be offered.<\/em><\/p>\n<h2>Embryo: biology and&nbsp;genetics<\/h2>\n<p><em><b>What kind of an embryo do we need to achieve a successful pregnancy and&nbsp;live birth?<\/b><\/em><\/p>\n<p><em>The human species is very complex with many various unique functions. It is not so\u00a0easy to pass on\u00a0to the next generation the entire heritage of important genetic information. An egg is a huge cell, visible even\u00a0to the naked eye. And\u00a0it contains a huge amount of valuable material! Not surprisingly, accurate cell division is not an easy task for\u00a0it to complete.<\/em><\/p>\n<p><em>As\u00a0a result, humans produce a big number of embryos with an abnormal set of chromosomes, which, oddly enough, is the biological norm for\u00a0our very complex and\u00a0highly developed species. Embryos with an abnormal chromosomal status usually stop developing and\u00a0do not lead to an ongoing pregnancy and\u00a0live birth.<b>\u00a0To achieve an ongoing pregnancy and\u00a0live birth, we need to find an embryo with a normal set of chromosomes.<\/b><\/em><\/p>\n<p><em>In&nbsp;O.L.G.A. Fertility the live birth rate per one embryo transfer of one blastocyst with a normal set of chromosomes is 51%. This means that&nbsp;out of 100 women who&nbsp;each had one embryo transfer of one blastocyst with a normal set of chromosomes, 51 will give birth.<\/em><\/p>\n<div class=\"fullw ctablock\">\n<p>We talk about the morphology and&nbsp;genetics of embryos at&nbsp;our free <a href=\"\/en\/events\/fertility-seminars-in-europe\/\">seminars<\/a> and&nbsp;<a href=\"\/en\/events\/online\/\">webinars<\/a>. We also discuss possible reasons of IVF failures, ways to overcome them, and&nbsp;we answer your questions. <br \/>\nPlease register and&nbsp;join our free webinar <a href=\"https:\/\/olgafertilityclinic.com\/en\/events\/webinar-what-does-olga-clinic-do-differently-in-ivf-with-own-eggs\/\">&#8220;What does OLGA Clinic do differently in&nbsp;IVF with own eggs?&#8221;<\/a><\/p>\n<p><a class=\"button\" href=\"\/en\/events\/webinar-what-does-olga-clinic-do-differently-in-ivf-with-own-eggs\/\">Register to our webinar<\/a><\/p>\n<\/div>\n<h2>Embryo: maths<\/h2>\n<h4><em><b>How many blastocysts with the normal number of chromosomes do we need on&nbsp;average to achieve live birth?<\/b><\/em><\/h4>\n<p><em>On&nbsp;average, to achieve live birth for&nbsp;each patient <b>we need to have 2-3 blastocysts with a normal number of chromosomes.<\/b><\/em><\/p>\n<h4><em><b>How many IVF cycles do we need to find one blastocyst with a normal set of chromosomes?<\/b><\/em><\/h4>\n<p><em>The number of IVF cycles depends on&nbsp;two main parameters:<\/em><\/p>\n<ul>\n<li><a href=\"#pp1\"><strong><em>The number of blastocysts we expect to get in&nbsp;one IVF cycle in&nbsp;an individual patient;<\/em><\/strong><\/a><\/li>\n<li><a href=\"#pp2\"><em><strong>The proportion of blastocysts with the normal set of chromosomes among those that&nbsp;we have managed to get.<\/strong><\/em><\/a><\/li>\n<\/ul>\n<div class=\"padleft\">\n<p><em><b><br \/>\nWhat does the number of blastocysts per one IVF cycle depend on?<\/b><b><\/b><\/em><\/p>\n<p><em>This number depends on:<\/em><em>\u00a0<\/em><\/p>\n<ul>\n<li><em>The number of eggs expected in\u00a0one IVF cycle in\u00a0an individual patient;<\/em><\/li>\n<li><em>The blastocyst formation rates \u2014 the proportion of fertilized eggs that\u00a0turn into blastocysts in\u00a0an individual egg and\u00a0sperm combination.<\/em><\/li>\n<\/ul>\n<p><em><b>What does the expected number of eggs per one IVF cycle depend on?<\/b><\/em><\/p>\n<p><em>The expected number of eggs in\u00a0an IVF cycle depends on\u00a0the woman\u2019s egg reserve. Women are born with their individual egg reserve.<\/em><\/p>\n<p><em><b>Which\u00a0proportion of the eggs received will successfully get fertilized?<br \/> Which&nbsp;proportion of the fertilized eggs will turn into blastocysts?<\/b><\/em><\/p>\n<p><em>It depends on\u00a0the potential of each egg + sperm combination, how this genetic material is going to work together. In\u00a0some egg + sperm combinations every second fertilized egg turns into a blastocyst, in\u00a0some \u2014 one in\u00a05, in\u00a0some even\u00a0none.<\/em><\/p>\n<\/div>\n<div class=\"fullw ctablock\">\n<p>We talk in&nbsp;detail about the classification and&nbsp;cultivation of embryos at&nbsp;our seminars and&nbsp;webinars, you are welcome to register and&nbsp;join.<\/p>\n<p><a class=\"button\" href=\"\/en\/events\/\">Register to our seminar<\/a><\/p>\n<\/div>\n<div class=\"padleft\">\n<p><b>What determines the proportion of blastocysts with a normal set of chromosomes?\u00a0\u2014 The woman\u2019s age.<\/b><b><\/b><\/p>\n<p><em>The higher the age of the woman is, the lower the percentage of chromosomally normal blastocysts formed from her eggs will be.<\/em><\/p>\n<p><em>For\u00a0example, at\u00a0the age of 35, one out of two blastocysts has a normal set of chromosomes, at\u00a0the age of 38 one out of three, at\u00a0the age of 43 \u2014 one out of eight.<\/em><\/p>\n<p><em>So, the higher the age is, the more blastocysts we need to find one blastocyst with a normal set of chromosomes.<\/em><\/p>\n<p><em>Let\u2019s remember that&nbsp;to reach a high probability of live birth, we need 2-3 blastocysts with a normal set of chromosomes, as&nbsp;the live birth rate per one embryo transfer of one blastocyst with a normal set of chromosomes at&nbsp;O.L.G.A. Fertility is 51%.<\/em><\/p>\n<p><em><b>We come to a rare situation where\u00a0if\u00a0quality suffers then quantity can help.\u00a0<\/b><\/em><\/p>\n<p><em>If, for\u00a0one reason or\u00a0another, in\u00a0an individual woman or\u00a0couple we expect to receive just a few blastocysts per one IVF cycle so\u00a0the probability of finding<span class=\"Apple-converted-space\">\u00a0 <\/span>2-3 chromosomally normal blastocysts within one IVF cycle is low, we can calculate in\u00a0advance the number of IVF cycles necessary for\u00a0this woman or\u00a0couple to find these 2-3 blastocysts with a normal set of chromosomes.<\/em><\/p>\n<p><em>If\u00a0the number of these IVF cycles, within which\u00a02-3 blastocysts with a normal set of chromosomes can be found, is foreseeable, we can offer the following conditions: we achieve a live birth within this fixed number of IVF cycles with own eggs or\u00a0refund 100% of the package\u2019s cost.<\/em><\/p>\n<h4><em><b>Let\u2019s have a look at&nbsp;two examples:<\/b><\/em><\/h4>\n<p><em><b>Example \u21161:<\/b><\/em><\/p>\n<p><em>Imagine my patient is 38 years old. At\u00a0the age of 38, one out of three blastocysts are chromosomally normal. So, I need to receive at\u00a0least 6 blastocysts to have a chance to find 2-3 blastocysts with a normal set of chromosomes for\u00a0this patient. But\u00a0based on\u00a0her reduced ovarian reserve, I expect her to have no more than\u00a02 blastocysts per one IVF cycle. However, within three IVF cycles I can get these 6 blastocysts. Thus, within three IVF cycles, I have a high probability of achieving a live birth for\u00a0my patient. So, I can offer this patient <b><em>\u201c<\/em><a href=\"\/en\/prices\/#part0\">3xIVF Package with 100% Money Back Guarantee of Live Birth<\/a>\u201d.<\/b><\/em><\/p>\n<p><em>If, after\u00a0analyzing your medical situation, we see that\u00a0receiving 2-3 blastocysts with a normal set of chromosomes is possible in\u00a0your case within three IVF attempts with your own eggs, we can offer you <b>\u201c<a href=\"\/en\/prices\/#part0\">3xIVF Package with <\/a><a href=\"\/en\/prices\/#part0\">100% Money Back Guarantee of Live Birth<\/a>\u201d.<\/b>\u00a0<\/em><\/p>\n<p><em><b><br \/>\nExample \u21162:<\/b><\/em><\/p>\n<p><em>Imagine my patient is 35 years old. At\u00a0the age of 35, one out of two blastocysts is chromosomally normal. So, I need to receive at\u00a0least 4 blastocysts to have a chance to find 2-3 blastocysts with a normal set of chromosomes. But\u00a0due to the reduced ovarian reserve, I expect this patient to have no more than\u00a01 blastocyst per one IVF cycle. However, within four IVF cycles, I can get these 4 blastocysts. It means that\u00a0within four IVF cycles I have a high probability of achieving a live birth for\u00a0this patient. So\u00a0I can offer her <b>\u201c<a href=\"\/en\/prices\/#part0\">4xIVF Package with <\/a><a href=\"\/en\/prices\/#part0\">100% Money Back Guarantee of Live Birth<\/a>\u201d.<\/b><\/em><\/p>\n<p><em>If, after\u00a0analyzing your medical situation, we see that\u00a0in\u00a0order to receive 2-3 blastocysts with a normal set of chromosomes, you will need at\u00a0least 4 IVF cycles, we can offer you <b>\u201c<a href=\"\/en\/prices\/#part0\">4xIVF Package with <\/a><a href=\"\/en\/prices\/#part0\">100% Money Back Guarantee of Live Birth<\/a>\u201d.<\/b><\/em><\/p>\n<hr class=\"w50p\" \/><\/div>\n<p><em>If, due to an advanced female reproductive age, reduced ovarian reserve, reduced blastocyst formation rates, or\u00a0a combination of these factors, the expected number of IVF attempts with own eggs to receive a blastocyst with a normal set of chromosomes is uncountable and\u00a0unpredictable, we will not be able to offer a money-back guarantee package with a fixed number of IVF attempts with own eggs. But\u00a0instead, we can discuss such a package with donor eggs , donor embryos or&nbsp;\u00a0a combined package.<\/em><\/p>\n<p><strong>Please see our <a href=\"https:\/\/olgafertilityclinic.com\/en\/prices\/\">web page for&nbsp;information about our 100% Money Back Guarantee of Live Birth Packages with own eggs, donor eggs, donor embryos or&nbsp;combination \u2192<\/a><\/strong><\/p>\n<div class=\"fullw ctablock\">\n<p>To discuss your individual situation, calculate the number of IVF attempts with own eggs till&nbsp;live birth and&nbsp;talk about possible alternatives, such as&nbsp;egg donation, double adoption or&nbsp;combined packages, please <b>book a consultation with one of our expert doctors.<\/b><\/p>\n<p>Before&nbsp;the consultation, we will ask you to provide us with detailed information about your medical history, test results and&nbsp;journals about your previous IVF attempts. This is usually dozens of pages of valuable information!<\/p>\n<p><b>We spend around 6-8 hours studying previous documentation of each new patient.<\/b> This helps us turn the years of previous bad luck into your potential happy future.<\/p>\n<p>The more accurate information about your medical history you give us, the more accurate prognosis and&nbsp;more successful strategy we can offer.<\/p>\n<p>When&nbsp;you come to us, <b>we<\/b> will be glad to meet you and&nbsp;<b>will make every effort so&nbsp;that&nbsp;in the foreseeable future we achieve our mutual result \u2014<\/b>\u00a0<b>a baby in&nbsp;your arms.<\/b><\/p>\n<p><a class=\"button\" href=\"#footerform\">Book a free individual consultation<\/a><\/p>\n<\/div>\n<h2>Q&amp;A<\/h2>\n<div>            <div class=\"qae-faqs-container qae-faqs-list-container\">\n\t\t\t\t\t\t\t<ul class=\"qe-faqs-filters-container\">\n\t\t\t\t<li class=\"active\"><a class=\"qe-faqs-filter all-faqs\" href=\"#\" data-filter=\"*\">All<\/a><\/li>\n\t\t\t\t<li><a class=\"qe-faqs-filter\" href=\"#ivf-math\" data-filter=\".ivf-math\">IVF Math<\/a><\/li>\t\t\t<\/ul>\n\t\t\t<ol class=\"qe-faqs-index-list\"><div id=\"qe-faqs-index\" class=\"qe-faqs-index\">\n\t\t\t\t\t<li class=\"ivf-math\">\n\t\t\t\t\t\t<a href=\"#qaef-12854\">Is it a good idea at all to try IVF if you only have one ovary?<\/a>\n\t\t\t\t\t<\/li>\n\n\t\t\t\t\n\t\t\t\t\t<li class=\"ivf-math\">\n\t\t\t\t\t\t<a href=\"#qaef-12855\">My AMH  level a year ago was 0.808 ng\/ML. I retested my AMH level last week and it is 0.148 which is lower than the average AMH  of 43 year olds. The average is typically between 0.4-0.6. Is it normal for AMH levels to drop in such a short time naturally?<\/a>\n\t\t\t\t\t<\/li>\n\n\t\t\t\t<\/div><\/ol>\t\t<div id=\"qaef-12854\" class=\"qe-faq-list ivf-math\">\n\t\t\t<div class=\"qe-list-title\">\n\t\t\t\t<h4>\n\t\t\t\t\t<i class=\"fa fa-question-circle\"><\/i> Is it a good idea at all to try IVF if you only have one ovary?\t\t\t\t<\/h4>\n\t\t\t<\/div>\n\t\t\t<div class=\"qe-list-content\">\n\t\t\t\t<p>It depends on&nbsp;your age and&nbsp;ovarian reserve which&nbsp;can be calculated by AMH and&nbsp;antral follicle count on&nbsp;ultrasound. If&nbsp;your age is less than&nbsp;44 and&nbsp;you have good ovarian reserve even&nbsp;in&nbsp;one ovary \u2014 it has no difference at&nbsp;all. There may be more eggs available in&nbsp;a single ovary of one individual than&nbsp;in&nbsp;both ovaries of another.<\/p>\n<p><em>Dr. Anna Gusareva<\/em><\/p>\n<br \/><a class=\"qe-faq-top\" href=\"#qe-faqs-index\"><i class=\"fa fa-angle-up\"><\/i> Back to Index<\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div id=\"qaef-12855\" class=\"qe-faq-list ivf-math\">\n\t\t\t<div class=\"qe-list-title\">\n\t\t\t\t<h4>\n\t\t\t\t\t<i class=\"fa fa-question-circle\"><\/i> My AMH  level a year ago was 0.808 ng\/ML. I retested my AMH level last week and it is 0.148 which is lower than the average AMH  of 43 year olds. The average is typically between 0.4-0.6. Is it normal for AMH levels to drop in such a short time naturally?\t\t\t\t<\/h4>\n\t\t\t<\/div>\n\t\t\t<div class=\"qe-list-content\">\n\t\t\t\t<p>AMH level can fluctuate but&nbsp;eventually will go down anyhow because&nbsp;it is an indirect measure of the ovarian reserve which&nbsp;can only decline with time. The pace of this decline is individual.<\/p>\n<p><em>Dr. Anna Gusareva<\/em><\/p>\n<br \/><a class=\"qe-faq-top\" href=\"#qe-faqs-index\"><i class=\"fa fa-angle-up\"><\/i> Back to Index<\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t            <\/div>\n\t\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Olga Zaytseff, an obstetrician-gynecologist and&nbsp;fertility specialist, the founder of O.L.G.A. Fertility: Dr.\u00a0Olga Zaytseff An obstetrician-gynecologist and&nbsp;fertility specialist, the founder of O.L.G.A. Fertility Let\u2019s start by defining what exactly we mean by the IVF success in&nbsp;O.L.G.A. Fertility. By the IVF success we mean not a completed IVF cycle, not a positive pregnancy test, and&nbsp;not even&nbsp;a<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":31,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>IVF Math - O.L.G.A. Fertility<\/title>\n<meta name=\"description\" content=\"Dr. Olga Zaytseff, the founder of O.L.G.A. Fertility explains the main principle of her work - a baby or money back - by listing factors that should be taken into account to achieve live birth and counting how many IVF cycles, eggs and embryos are needed for successful outcome. Discover optimal strategies, options and offers. 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