{"id":5985,"date":"2020-06-15T12:00:00","date_gmt":"2020-06-15T12:00:00","guid":{"rendered":"https:\/\/olgafertilityclinic.com\/embryo\/"},"modified":"2020-06-15T12:00:00","modified_gmt":"2020-06-15T12:00:00","slug":"embryo","status":"publish","type":"page","link":"https:\/\/olgafertilityclinic.com\/en\/embryo\/","title":{"rendered":"Vitrification of embryos(freezing)"},"content":{"rendered":"<h2>Vitrification of embryos<\/h2>\n<p>If&nbsp;during IVF or&nbsp;ICSI procedure more embryos were obtained than&nbsp;are going to be transferred into the uterus, these embryos, if&nbsp;of good quality, can be frozen. These frozen embryos are the property of the couple alone and&nbsp;can be used for&nbsp;the next attempt or&nbsp;a next pregnancy. They may be required if&nbsp;you have not got pregnant in&nbsp;the fresh try or&nbsp;if you have got pregnant and&nbsp;want a brother or&nbsp;sister for&nbsp;your first child several years later. The benefit of cryopreservation is that&nbsp;a woman has an additional chance to conceive without new stimulation procedure and&nbsp;follicular puncture. She only needs to prepare for&nbsp;the embryo transfer with tablets. This process starts in&nbsp;the first 3 days of menstruation, lasts for&nbsp;two weeks and&nbsp;requires 1-2 US examinations.<\/p>\n<p>Embryo cryopreservation&nbsp;is the process of preserving an embryo at&nbsp;sub-zero temperatures, generally at&nbsp;an&nbsp;<a href=\"http:\/\/en.wikipedia.org\/wiki\/Embryogenesis\" rel=\"nofollow\" title=\"Embryogenesis\">embryogenesis<\/a>&nbsp;stage corresponding to pre-implantation.<\/p>\n<p>The first delivery in&nbsp;the World after&nbsp;frozen embryo transfer took place in&nbsp;1984. Since&nbsp;then and&nbsp;up to 2008 it is estimated that&nbsp;between 350,000 and&nbsp;half a million IVF babies have been born from frozen embryos. Pregnancies have been reported even&nbsp;from embryos stored for&nbsp;16 years [<a href=\"#refs\">1<\/a>].&nbsp; Numeral studies, dedicated to the possible increased birth abnormalities in&nbsp;children born from frozen embryos showed no risk elevation in&nbsp;birth abnormalities after&nbsp;frozen embryo transfer [<a href=\"#refs\">2<\/a>]. The duration of storage doesn&rsquo;t have any significant effect on&nbsp;clinical pregnancy, miscarriage, implantation, or&nbsp;live birth rate, whether&nbsp;from IVF or&nbsp;oocyte donation cycles [<a href=\"#refs\">3<\/a>].<\/p>\n<p>Vitrification now&nbsp;is considered the most effective method of embryo cryopreservation and&nbsp;performed mostly in&nbsp;all IVF clinics all other the world. But&nbsp;the research continues in&nbsp;this area and&nbsp;human embryo freezing and&nbsp;thawing protocols have improved tremendously over the past 25 year.<\/p>\n<div id=\"imgr\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"153\" src=\"\/p\/en\/488-2.jpg\" width=\"200\" \/><\/div>\n<p>O.L.G.A. Fertility Clinic owns one of the biggest embryo cryobanks in&nbsp;RF, which&nbsp;we use to store donor embryos and&nbsp;embryos of our patients. We have been using embryo vitrification since&nbsp;2009 with a help of Kuwayama method and&nbsp;Cryotop systems. Cryopreservation is performed on&nbsp;day 5 or&nbsp;day 6 of embryogenesis.<\/p>\n<h3>O.L.G.A. Fertility Clinic Comparative results of Vitrification and&nbsp;Slow Freezing on&nbsp;day 5:<\/h3>\n<table border=\"0\" cellpadding=\"1\" cellspacing=\"1\" class=\"data\">\n<tbody>\n<tr>\n<td rowspan=\"2\" valign=\"top\">\n<p>&nbsp;<\/p>\n<p>Average survival rate of embryos<\/p>\n<\/td>\n<td valign=\"top\">\n<p>Vitrification Day 5<\/p>\n<\/td>\n<td valign=\"top\">\n<p>Vitrification Day 6<\/p>\n<\/td>\n<td valign=\"top\">\n<p>Slow freezing<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\">\n<p>77%<\/p>\n<\/td>\n<td valign=\"top\">\n<p>78,5%<\/p>\n<\/td>\n<td valign=\"top\">\n<p>62%<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\">\n<p>Implantation rate<\/p>\n<\/td>\n<td valign=\"top\">\n<p>30%<\/p>\n<\/td>\n<td valign=\"top\">\n<p>&#8211;<\/p>\n<\/td>\n<td valign=\"top\">\n<p>&#8211;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\">\n<p>Clinical pregnancy rate<\/p>\n<\/td>\n<td valign=\"top\">\n<p>43%<\/p>\n<\/td>\n<td valign=\"top\">\n<p>47%<\/p>\n<\/td>\n<td valign=\"top\">\n<p>26%<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\">\n<p>Pregnancy loss rate<\/p>\n<\/td>\n<td valign=\"top\">\n<p>21%<\/p>\n<\/td>\n<td valign=\"top\">\n<p>13%<\/p>\n<\/td>\n<td valign=\"top\">\n<p>26%<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>The results of O.L.G.A. Fertility Clinic work are consistent with the conclusions set out in&nbsp;a number of European researches, showing that&nbsp;the higher pregnancy rate commonly observed when&nbsp;using vitrification.<\/p>\n<p>Cryopreservation of surplus embryos is a biological &quot;support&quot; for&nbsp;the couple since&nbsp;it is not always clear whether&nbsp;the next possible stimulation and&nbsp;fertilization attempt will be successful. Embryo cryopreservation increases the couple&#39;s chances to conceive. Embryo cryopreservation is fairly economical since&nbsp;preservation, unfreezing and&nbsp;embryo transfer costs are much lower compared to the cost of a new IVF attempt.<\/p>\n<p>The cryopreservation is a reliable and&nbsp;trusted approach. It has no negative impact on&nbsp;the fetus and&nbsp;pregnancy. Embryo cryopreservation makes the treatment milder and&nbsp;more economical.<\/p>\n<p>&nbsp;<\/p>\n<p><a id=\"refs\" name=\"refs\"><\/a>References:<\/p>\n<p>1. &nbsp;<a href=\"http:\/\/www.planer.com\/PlanerComWebsite.nsf\/7dc62b5d9e44dd40802575460048fc4e\/76a07726303dac468025757d005b004d?OpenDocument\" rel=\"nofollow\">Planer NEWS and&nbsp;Press Releases &#39;Twins&#39; born 16 years apart.<\/a>&nbsp;01\/06\/2006<br \/>\n2. &nbsp;<a href=\"http:\/\/web.archive.org\/web\/*\/http:\/givf.com\/embryov.cfm\" rel=\"nofollow\">&quot;Genetics &amp; IVF Institute&quot;<\/a>. Givf.com. Archived from&nbsp;<a href=\"http:\/\/www.givf.com\/fertility\/embryofreezing.cfm\" rel=\"nofollow\">the original<\/a>&nbsp;on 2009-07-27. Retrieved&nbsp; 2009-07-27.<br \/>\n3. Riggs R, Mayer J, Dowling-Lacey D, Chi TF, Jones E, Oehninger S (November 2008). &quot;Does storage time influence postthaw survival and&nbsp;pregnancy outcome? An analysis of 11,768 cryopreserved human embryos&quot;.&nbsp;Fertil. Steril.&nbsp;93&nbsp;(1): 109&ndash;15.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vitrification of embryos If&nbsp;during IVF or&nbsp;ICSI procedure more embryos were obtained than&nbsp;are going to be transferred into the uterus, these embryos, if&nbsp;of good quality, can be frozen. These frozen embryos are the property of the couple alone and&nbsp;can be used for&nbsp;the next attempt or&nbsp;a next pregnancy. They may be required if&nbsp;you have not got pregnant<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":49,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Embryo cryopreservation or freezing - Vitrification of embryos<\/title>\n<meta name=\"description\" content=\"The embryo cryopreservation is a reliable and trusted approach. 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