{"id":10650,"date":"2021-07-02T08:25:32","date_gmt":"2021-07-02T08:25:32","guid":{"rendered":"https:\/\/olgafertilityclinic.com\/?p=10650"},"modified":"2024-06-25T12:12:12","modified_gmt":"2024-06-25T12:12:12","slug":"madeleine-sina-ivf-pgs-pgt-a-era","status":"publish","type":"post","link":"https:\/\/olgafertilityclinic.com\/en\/success-stories\/madeleine-sina-ivf-pgs-pgt-a-era\/","title":{"rendered":"After 10 years of endless attempts Madeleine and Sina finally became parents to their little baby girl Wilma, using their own eggs and own sperm"},"content":{"rendered":"<p><img decoding=\"async\" class=\"w30p ar\" src=\"https:\/\/olgafertilityclinic.com\/wp-content\/uploads\/2021\/07\/image4_2.jpeg\" \/><\/p>\n<p><strong>Dr. Olga Zaytseff:<\/strong><\/p>\n<p><em>&#8220;A huge dramatic chapter in&nbsp;my heart has finally closed and&nbsp;a rock fell off my shoulders when&nbsp;Madeleine <a href=\"https:\/\/www.instagram.com\/maddymalmstrom\/\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">@maddymalmstrom<\/a> and&nbsp;Sina <a href=\"https:\/\/www.instagram.com\/sinakes\/\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">@sinakes <\/a>wrote this e-mail to us 26 May:<\/em><\/p>\n<blockquote>\n<p>Dear Team O.L.G.A., Our dear baby girl <em>Wilma joined us 21 May 04:58. <br \/>\nThis would not have been possible without your expertise, your encouragement and&nbsp;faith in&nbsp;a positive outcome. With your help we have succeeded in&nbsp;an almost 10 year difficult journey, in&nbsp;essence our entire thirties. So&nbsp;from the bottom of our hearts thank you\u201d<\/em><\/p>\n<\/blockquote>\n<p><em>Dear Team, thank you from the bottom of my heart to everyone who&nbsp;has contributed your knowledge, skills and&nbsp;support and&nbsp;made it possible for&nbsp;this dear couple to finally become parents!<\/em><\/p>\n<p><em>Dear Madeleine and&nbsp;Sina, I feel gratefulness and&nbsp;relief that&nbsp;this chapter is completed with the birth of your little girl, using your own egg and&nbsp;own sperm. I am so&nbsp;glad no surrogacy or&nbsp;donation was necessary in&nbsp;the end. We wish the dear three of you lots of love, happiness and&nbsp;good health and&nbsp;a warm large family!\u201d<\/em><\/p>\n<div class=\"inset w50p\"><img decoding=\"async\" class=\"w100p\" style=\"margin: 2rem 0 .6rem 0;\" src=\"https:\/\/olgafertilityclinic.com\/wp-content\/uploads\/2021\/07\/1-1.jpg\" alt=\"\" \/><\/p>\n<p class=\"caption al\">ALLAS.se, Sweden | 09 June, 2021<br \/>\n<a href=\"https:\/\/www.allas.se\/samhalle\/forsokt-fa-barn-i-tio-ar-antligen-en-dotter\/7502276\" target=\"_blank\" rel=\"noopener\">Read the full article in&nbsp;Swedish\u00a0\u2192<\/a><br \/>\n<a href=\"https:\/\/olgafertilityclinic.com\/en\/press\/madeleine-sina-ivf-pgs-pgt-a-era-test\/\">The translation in&nbsp;English is available here \u2192<\/a><\/p>\n<\/div>\n<h3>Madeleine and&nbsp;Sina shared in&nbsp;their interview to allas.se:<\/h3>\n<blockquote>\n<p>It feels absolutely fantastic. The opportunity to experience this can hardly be described. Right now, the most dominant feeling is gratitude and&nbsp;a lot of love. We enjoy our little treasure. Every day is a gift because&nbsp;we have lived with the option of being without our daughter for&nbsp;almost ten years. So&nbsp;for&nbsp;us, she is not just a child but&nbsp;a miracle, a real miracle.\u201d<\/p>\n<\/blockquote>\n<h3>But&nbsp;Madeleine and&nbsp;Sina still very much remember the thoughts and&nbsp;the feelings of these past 10 years:<\/h3>\n<blockquote>\n<p><em>\u2026 <\/em>My entire 30s I spent trying to have children. Life was on&nbsp;hold; I hardly remember anything from these years now&nbsp;in retrospect. We lived in&nbsp;this world all the time, ate and&nbsp;slept in&nbsp;it. I feel disappointed about this period of my life&#8221; \u2014 says Madeleine<\/p>\n<\/blockquote>\n<blockquote>\n<p>\u2026If you love each other, you want to be as&nbsp;close to each other as&nbsp;possible and&nbsp;for&nbsp;us it means having a child together. I want a child who&nbsp;is half her and&nbsp;half me. People say that&nbsp;their children are the biggest thing that&nbsp;has happened in&nbsp;their lives, but&nbsp;at the same time they say that&nbsp;it is not for&nbsp;everyone, and&nbsp;one can still be fine anyway. It is to diminish one&#8217;s situation&#8221; \u2014 Sina says<\/p>\n<\/blockquote>\n<h3>Do these thoughts and&nbsp;feelings resonate with your own?<\/h3>\n<ul>\n<li><strong>Educate yourself<\/strong>!<br \/>\nFind out more about modern methods and&nbsp;options in&nbsp;our webinars, that&nbsp;we arrange in&nbsp;zoom every Wednesday at&nbsp;18:00 CEST. Our webinars are free.\u00a0<strong><a href=\"https:\/\/olgafertilityclinic.com\/en\/events\/\">Just register and&nbsp;join \u2192<\/a><\/strong><\/li>\n<li><strong>Get motivation, inspiration and&nbsp;hope<br \/>\n<\/strong>by joining our regular InstaLive sessions every Monday at&nbsp;19:00 CEST at&nbsp;<a href=\"https:\/\/instagram.com\/dr.olga.zaytseff\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">@dr.olga.zaytseff<\/a><br \/>\nEvery time we have a guest \u2013 one of our dear patient, willing to share her story and&nbsp;successful process in&nbsp;our clinic. Dr. Olga and&nbsp;our Team Experts join to explain methodology and&nbsp;answer your questions. Finding successful solutions in&nbsp;situations similar to yours may give you back hope and&nbsp;motivation.<\/li>\n<li><strong>Book yourself a free second opinion consultation\u00a0<br \/>\n<\/strong>with one of our fertility specialists.\u00a0it is free!<strong><br \/>\n<\/strong><br \/>\n<a class=\"button\" href=\"https:\/\/olgafertilityclinic.com\/en\/contacts\/how-to-start\/\">Book consultation now<\/a><br \/>\n<strong><br \/>\nGet our proposal of strategy, package and&nbsp;next steps written in&nbsp;our Doctors\u2019 letter \u2014 it is free also!<br \/>\n<\/strong><strong>Then sit down, read it and&nbsp;reflect on&nbsp;what you wish to do.<\/strong><\/li>\n<\/ul>\n<div class=\"fullw cf\" style=\"background-color: #f7f3ed;\">\n<div class=\"cont\">\n<h2><img decoding=\"async\" class=\"w40p ar\" src=\"https:\/\/olgafertilityclinic.com\/wp-content\/uploads\/2021\/07\/83895808_1328519927333866_2841726768781327424_n.jpg\" \/>Dr. Olga and&nbsp;Dr. Elena explain the process and&nbsp;the methods which&nbsp;have helped Sina and&nbsp;Madeleine to become parents and&nbsp;have their daughter Wilma using their own egg and&nbsp;own sperm<\/h2>\n<h3>Dr. Olga explains:<\/h3>\n<p>I remember very well how Madeleine and&nbsp;Sina came to my seminar in&nbsp;Gothenburg in&nbsp;August 2018 \u2013 a very lovely couple. Sina had many questions in&nbsp;the seminar, which&nbsp;woke up the audience and&nbsp;created a very nice discussion after&nbsp;the lecture. Such an energetic happy couple in&nbsp;their middle of 30s! Who&nbsp;would have guessed that&nbsp;since&nbsp;2002 Madeleine and&nbsp;Sina were desperately trying to become parents!<\/p>\n<p>We had a personal consultation after&nbsp;the seminar, and&nbsp;Sina and&nbsp;Madeleine have shared with me the details of their story.<\/p>\n<p>At&nbsp;that time Madeleine, 35 and&nbsp;Sina, 37, were already together 16 years.\u00a0 Since&nbsp;2002 they have already been through 3 ectopic pregnancies and&nbsp;4 laparoscopic surgeries with both fallopian tubes removed. After&nbsp;the miscarriage in&nbsp;2012 Madeleine has been through 2 hysteroscopies due to possible rests.<\/p>\n<p>Since&nbsp;2012 Madeleine and&nbsp;Sina have undergone 9 egg retrievals and&nbsp;9 fresh and&nbsp;1 frozen embryo transfers with just one pregnancy, which&nbsp;has sadly ended in&nbsp;missed abortion.<\/p>\n<p>Madeleine had a good follicular reserve, and&nbsp;I could not understand why&nbsp;each <a href=\"\/en\/ivf\/\">IVF<\/a> has yielded only 1-2 embryos available, even&nbsp;if&nbsp;the embryos were mostly grown 2-3 days. I felt Madeleine\u2019s potential was much better than&nbsp;just 1-2 embryos per IVF cycle. I have focused on&nbsp;analyzing her papers. My goal was to turn negative history into future success. In&nbsp;her past unsuccessful stimulations, I looked for&nbsp;the recipe of successful stimulation.<\/p>\n<p>I have confirmed the 3IVF package with guarantee of live birth without <a href=\"\/en\/pgt-a\/\">PGT-A<\/a>. Guarantee if&nbsp;live birth meant that&nbsp;we would refund the money paid if&nbsp;no live\u00a0birth was achieved within 3 IVF cycles. I have offered the cheapest package without PGT-A since&nbsp;at&nbsp;that time there was no evidence that&nbsp;PGT-A increases live birth rates per transfer in&nbsp;women 35 years old and&nbsp;younger, since&nbsp;the majority of their blastocysts is expected to be chromosomally normal.<\/p>\n<p>I have created an individual stimulation protocol which&nbsp;I have put my hopes into and&nbsp;followed Madeleine through her stimulation on&nbsp;distance when&nbsp;she was doing injections and&nbsp;ultrasound examinations and&nbsp;sent me her results for&nbsp;tuning in&nbsp;the dosage.<\/p>\n<h3>Dr. Elena explains:<\/h3>\n<p>When&nbsp;Madeleine and&nbsp;Sina came to St. Petersburg in&nbsp;January 2019, we got 10 blastocysts of excellent and&nbsp;good morphology!<\/p>\n<p>10 blastocysts in&nbsp;one IVF cycle vs 11 embryos of day 2-3-5 in&nbsp;9 IVF cycles previously!<\/p>\n<p>We have safely frozen the 10 blastocysts. The first milestone was completed.<\/p>\n<p>Now&nbsp;we could focus on&nbsp;preparing the uterus for&nbsp;embryo transfer.<\/p>\n<p>In&nbsp;March 2019 did hysteroscopy with histological and&nbsp;microbiological testing. I found signs of scar tissue and&nbsp;inflammation. We removed the scar\u00a0tissue during hysteroscopy. Madeleine and&nbsp;Sina have got individual antibacterial therapy on&nbsp;several occasions. Madeleine has received anti-inflammatory and&nbsp;hormonal treatment for&nbsp;several weeks after&nbsp;hysteroscopy.<\/p>\n<p>After&nbsp;single blastocyst transfer in&nbsp;May 2019 the pregnancy test came back negative.<\/p>\n<p>After&nbsp;double embryo transfer in&nbsp;July 2019 HCG was 6<\/p>\n<p>In&nbsp;Nov 2020 ERA test showed the displacement of the implantation window. The above two embryo transfers were done 127h after&nbsp;the beginning of progesterone supplementation, but&nbsp;based on&nbsp;the result of the ERA test, Madeleine had her individual implantation window 19h later: 146 h after&nbsp;the beginning of progesterone supplementation.<\/p>\n<p>The next double embryo transfer in&nbsp;January 2020 was done already 146h after&nbsp;the beginning of progesterone based on&nbsp;Madeleine\u2019s individual implantation window. HCG came back 80, went up to 160 and&nbsp;sadly after&nbsp;this declined.<\/p>\n<p>3 transfers of 5 excellent looking blastocysts, resulted in&nbsp;one implantation failure and&nbsp;two early pregnancy losses. We always knew that&nbsp;the main reason for&nbsp;implantation failures and&nbsp;early pregnancy losses was due to abnormal numbers of chromosomes in&nbsp;embryos. What we could not have expected was such a high proportion of abnormal embryos at&nbsp;the age of 35!<\/p>\n<p>Sina and&nbsp;Madeleine had the same thoughts. In&nbsp;fact they were the driving force which&nbsp;requested that&nbsp;the remaining 5 blastocysts be thawed, biopsied and&nbsp;tested before&nbsp;potential next transfer!<\/p>\n<p>Said \u2013 done! Out of 5 blastocysts tests were possible on&nbsp;4 of them. The result came back overwhelming: out of 4 blastocysts only one chromosomally normal and&nbsp;3 abnormal.<\/p>\n<p>The ending of the story you might already anticipate: In&nbsp;September 2020 I transferred one embryo normal for&nbsp;23 chromosomes into Madeleine\u2019s individual implantation window. This embryo became Wilma.<\/p>\n<h3>Conclusion:<\/h3>\n<p><strong>It may feel that&nbsp;using additional tests such as&nbsp;PGT-A and&nbsp;ERA takes additional effort and&nbsp;money, and&nbsp;takes time so&nbsp;that&nbsp;the embryo transfer is done later rather&nbsp;than&nbsp;sooner.<\/strong><\/p>\n<p><strong>But&nbsp;this story very clearly shows that&nbsp;just on&nbsp;the opposite: PGT-A and&nbsp;ERA tests do shorten time to ongoing pregnancy and&nbsp;baby, also in&nbsp;younger patients.<\/strong><\/p>\n<\/div>\n<\/div>\n<h3>Interested?\u00a0Having questions?<\/h3>\n<p><!--\n\n\n\n\n\n<ul>\n\t\n\n<li><strong>Educate yourself!<\/strong><br \/>\nFind out more about modern methods and&nbsp;options in&nbsp;our webinars, that&nbsp;we arrange in&nbsp;zoom every Wednesday at&nbsp;18:00 CEST. Our webinars are free \u2014 <a href=\"https:\/\/olgafertilityclinic.com\/en\/events\/\">just register and&nbsp;join \u2192<\/a><\/li>\n\n\n<\/ul>\n\n\n\n\n<ul>\n\t\n\n<li><strong>Get motivation, inspiration and&nbsp;hope<\/strong><br \/>\nby joining our regular InstaLive sessions every Monday at&nbsp;19:00 CEST at&nbsp;<a href=\"https:\/\/instagram.com\/dr.olga.zaytseff\" target=\"_blank\" rel=\"noopener\">@dr.olga.zaytseff<\/a><br \/>\nEvery time we have a guest \u2013 one of our dear patient, willing to share her story and&nbsp;successful process in&nbsp;our clinic. Dr. Olga and&nbsp;our Team Experts join to explain methodology and&nbsp;answer your questions. Finding successful solutions in&nbsp;situations similar to yours may give you back hope and&nbsp;motivation.<\/li>\n\n\n\t\n\n<li><strong>Book yourself a free second opinion consultation<\/strong><br \/>\nwith one of our fertility specialists. It is free!\n\n\n<a class=\"button\" href=\"https:\/\/olgafertilityclinic.com\/en\/contacts\/how-to-start\/\">Book consultation now<\/a>\n\n\nGet our proposal of strategy, package and&nbsp;next steps written in&nbsp;our Doctors\u2019 letter\u2013 it is free also!<br \/>\nThen sit down, read it and&nbsp;reflect on&nbsp;what you wish to do.<\/li>\n\n\n<\/ul>\n\n\n\n\n--><\/p>\n<p><a class=\"button\" href=\"https:\/\/olgafertilityclinic.com\/en\/contacts\/how-to-start\/\">Book consultation now<\/a><\/p>\n<p><strong>\u00a0\u00a0<\/strong><\/p>\n<div class=\"fullw cf\" style=\"background-color: #f7f3ed; padding-top: 2.2rem;\">\n<div class=\"cont\">\n<p><a href=\"https:\/\/www.instagram.com\/reel\/Cxdw3GSMeBS\/\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" class=\"w40p fr\" src=\"https:\/\/olgafertilityclinic.com\/wp-content\/uploads\/2021\/07\/20230921cover-1-1064x1600.jpg\" alt=\"\" \/><\/a>As&nbsp;confirmation to the above:<\/p>\n<p>In&nbsp;July 2022 Madeleine and&nbsp;Sina came back to St. Petersburg to have a brother or&nbsp;a sister to Wilma:16 eggs were collected, 8 blastocysts grew, 2 of them were found to be chromosomally normal and&nbsp;one little embryo was transferred in&nbsp;November 2022 which&nbsp;became sweet Walter who&nbsp;has just turned 2 months.<\/p>\n<p>This process took just two visits to St. Petersburg with 3 months apart even&nbsp;Madeleine was almost 40.<\/p>\n<p>Dear Madeleine <a href=\"https:\/\/instagram.com\/maddymalmstrom\" target=\"_blank\" rel=\"noopener\">@maddymalmstrom<\/a> and&nbsp;Sina <a href=\"https:\/\/instagram.com\/sinakes\" target=\"_blank\" rel=\"noopener\">@sinakes<\/a>, congratulations to your little baby boy Walter and&nbsp;to becoming a family of four together with your sweet daughter Wilma \u2764\ufe0f\u2764\ufe0f\u2764\ufe0f\u2764\ufe0f<\/p>\n<p>Dear Madeleine, thank you so&nbsp;much for&nbsp;having joined our seminar in&nbsp;Gothenburg this August and&nbsp;bringing inspiration, reassurance, hope and&nbsp;belief to our patients \ud83e\udef6\ud83e\udef6\ud83e\udef6<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Dear Team O.L.G.A., Our dear baby girl Wilma joined us 21 May 04:58. This would not have been possible without your expertise, your encouragement and faith in a positive outcome. With your help we have succeeded in an almost 10 year difficult journey, in essence our entire thirties&#8221; &#8211; Madeleine and Sina<\/p>\n","protected":false},"author":1,"featured_media":10651,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[12,11,24],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>After 10 years of endless attempts Madeleine and Sina finally became parents to their little baby girl Wilma, using their own eggs and own sperm - O.L.G.A. Fertility<\/title>\n<meta name=\"description\" content=\"Follow a hard 10-years journey of Madeleine and Sina to their long-awaited miracle Wilma who was conceived through IVF with their own egg and sperm. 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