PGS benefit

4 randomized controlled trials have recently shown that PGS  for 23 chromosome pairs increases implantation rates at least by 1/3.

PGD for 23 chromosome pairs increases implantation rates at least by 1/3.

Randomized controlled trials Patient group Fresh or freezing Implantation rate after PGD for 23 chromosome pairs vs control
Yang et al. 2012 <35 day 5 biopsy, day 6 fresh transfer 40% increase
Schoolcraft et al. 2012 >35 (av 39) day 5 biopsy, freezing, FET 32% increase
Forman et al. 2013 >35 day 5 biopsy, day 6 fresh transfer 32% increase
Scott et al. 2013 20-42 (av. 32) day 5 biopsy, day 6 fresh transfer 28% increase

 

For example :

Schoolcraft et al. 2012 have shown in women above 35 year old (mean age 39) implantation rates is 56,7% after PGS for 23 chromosome pairs and only 38% implantation rates in controls after frozen embryo transfer. Miscarriage rates in control group were 17% and 0% after PGS.

The same results were shown in 2013 by Forman et al in the same patient group (women in the age 35 or older: 58,3% implantation rates in PGS group and 39,8% implantation rates in control group.

In summary the benefit of PGS for 23 chromosome pairs is:

  • Helps to choose the right embryo for transfer to the uterus not only on the basis of “good looks” but also with the knowledge of correct chromosome set
  • Increases pregnancy and live birth rates per embryo transfer
  • Reduces time to pregnancy via excluding chromosomally abnormal good looking embryos from usage
  • Helps to avoid unnecessary embryo transfers
  • Helps to avoid freezing of chromosomally abnormal embryos
  • Reduces miscarriage rates
  • Reduces the Down syndrome risk
  • Explains multiple unsuccessful IVFs (RIF)
  • Eliminates negative effect of maternal age on implantation

“…When I left the clinic and walked down the Nevsky Prospect I knew I was pregnant — and the feeling was right! 9 month after her visit at the AVA Clinic Alexander was born!”

Ewa and Sten

"...If I would have known at the start, what I know now, I would not have done my IVF-attempts at my age as egg donation gave us result straight away. It was the best decision of our lives!"

Karin and Pedro, Sweden

“…I am a single woman and when one is lonely, one is very sensitive…You saw me as a person and I felt that you can help me…”

Birgita

 


Having questions? Ask our doctors now!

A blog by Tone Bråten

A blog — to help you on your journey to become parents!

Our patients tell their stories



  •    
    The Egg Solution
    Aftenposten, 27 September 2019, Norway. Miriam Lund Knapstad, Helle Aarnes
    More
    Olga is the miracle doctor who gives baby guarantee
    ALLAS.se, Sweden. 6 August 2019. Text & Malin Aunsbjerg
    More
    Cilla Holm became a mother on her own – this is her new Liv (life)
    Dagens Nyheter, Sweden. 7 May 2019
    More
    Russian baby guarantee is the Swedes’ last chance
    Svenska Dagbladet, Sweden. 7 April 2019
    More
    Mum through embryo donation
    Marie Granmar is my very dear patient from more than 8 years ago. Please listen to Marie’s interview on TV4 7 March 2019 in Sweden
    More
    "I became pregnant with an embryo adoption”
    One more story about our dear patient Cilla Holm by Tara Magazine, Sweden
    More
    Titiyo became this year's Comeback Mum: "I've broken the norm"
    More
    Monika and André pay 240,000 SEK for having a child
    More
    "Had to travel abroad to get pregnant after 8 IVF attempts in Norway"
    Interview with our patient Elin Renate by TV2 Norway
    More
    Report on us on Norwegian Television TV 2
    More
    Enjoy our dear patient Cilla's story, who has been interviewed by the "Dagens Nyheter", daily newspaper in Sweden
    More
    Report on us and our dear patient Hillevi on SVTPlay & SVTNews
    More
    FacebookInstagram